Endocrine Abstracts

Endogenous as well as exogenous androgens and oestrogen have neuroprotective properties. Oestrogen is formed locally in neural tissue from precursor androgens. In the brain, the expression of aromatase, the enzyme that catalyses the conversion of androgens to oestrogen, is restricted, under normal circumstances, to specific neuronal populations involved in neuroendocrine control and in the modulation of reproductive or sexually dimorphic behaviours. However, the expression of ...

Introduction: Pheochromocytomas (PCCs) and paragangliomas (PGL) are rare but unique tumors. Only 10% of PCCs are malignant, defined by metastases. Metastases can be seen at diagnosis of the primary tumor or develop even 20 years later. Approximately half of patients with metastatic PCC/PGL have inherited SDHB mutations.Case report: A 45-year-old man was referred to Urology for curvature of the penis and painful erections. Among his medical background hig...

Introduction: Vitamin D insufficiency is very common among Spanish adults. It is well established there is an inverse relationship between vitamin D and PTH levels. The diagnostic approach of an increased serum PTH concentration in a normocalcemic normophosphatemic patient is frequent in routine practice and the deficiency of vitamin D is the major cause of secondary hyperparathyroidism (SHPT). The aims of this study were to evaluate the prevalence of SHPT in a cohort of normo...

Introduction: Cyclic Cushing’s syndrome (CS) is a rare disorder characterized by repeated episodes of cortisol excess interspersed by periods of normal cortisol secretion. These phases may range from days to years. The diagnosis is a difficult challenge.Case report: We present a case of 56-year-old women with hyperglycemia, hypertension, central obesity, edema, bruising, fatigue and emotional lability for several years. Laboratory tests: glucose 141...

Pituitary stem cells have been characterized in the postnatal pituitary. We now know they are organized in a niche and co-express specific markers such as Sox2, Sox9 or Gfra2. Although many studies by our group and others have been dedicated to its characterization in situ it is under discussion their role in the maintenance and turnover of the pituitary in physiological conditions or physiological pituitary challenges. It’s not known if the stem cells are requir...

Introduction: Postoperative hypocalcemia is among the most frequent morbidities after total thyroidectomy. Although most postoperative hypocalcemia is temporary, it causes prolonged hospitalization and a decrease in quality of life. For all this, early diagnosis is essential to start treatment as soon as possible. In this study, we determined whether early serum calcium levels can predict the development hipoparathyroidism.Methods: A total of 122 patient...

Introduction: There are known biological differences between men and women in coronary heart disease. It is important to know these differences in order to avoid inequalities in prevention, diagnosis and treatment of this pathology.Methods: We designed a retrospective, descriptive study in which we included all diabetic patients admitted to the hospital with acute coronary syndrome in 2016. Demographic data and degree of control of risk factors were regi...

Introduction: Amiodarone is an antiarrhythmic drug whose high iodine content may influence thyroid function. The first line treatment of amiodarone-induced hyperthyroidism (AIH) is mainly medical. Plasmapheresis has been used in cases of antithyroid intolerance or refractory hyperthyroidism, although clinical experience is poor.Clinical case: We present a case of a patient with structural heart disease and severe AIH refractory to medical treatment who r...

Objective: The aim of this study was to evaluate maternal and perinatal outcomes before and after implementation of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for testing of gestational diabetes mellitus (GDM).Methods: This is a retrospective cohort study of women with GDM followed at a single university hospital. We compared maternal and neonatal outcomes of singleton pregnancies in women with GMD before (from...

Introduction: Modifications of gut microbiota have been described in relation to inflammatory bowel disease (IBD), dietary habits and nutritional status.Objective: To relate gut microbial pattern of patients with IBD compared to healthy individuals; and link gut microbial pattern with activity of the disease, nutritional status and dietary habit.Material and methods: Observational study of 56 subjects (44 with IBD and 12 controls)....